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WSB-1

[WD repeat and socs box-containing protein-1] Vasiliauskas et al (1999). The protein contains 8 WD repeats and a C-terminal SOCS box. Chicken SWIP1 [SOCS box and WB repeats in protein 1] and human WSB-1 share 88 % amino acid identity. Vasiliauskas et al (1999) have reported that WSB-1 is regulated by sonic hedgehog signaling in somites and limb buds in developing chicken.

Dentice et al (2005) have reported that WSB-1 is part of an E3 ubiquitin ligase complex that modulates thyroid hormone activation and PTHrP secretion in the developing growth plate and thereby regulates chondrocyte differentiation. ... ... ... ... ... Subscribe to continue reading! ... ...

 

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