Tob

[transducer of erbB2] called also TOB1 ([transducer of erbB2 1] approved gene symbol). This 45 kDa protein has been identified by virtue of its ability to interact with the neu oncogene protein (Matsuda et al, 1996). Tob does not contain either SH2 domains or SH3 domains (see: scr homology domains) but is homologous to the antiproliferative gene product BTG1 at its amino-terminal half. Tob is a member of the BTG family of antiproliferative proteins. Related proteins are AmphiTob and Tob2. Ezzeddine N et al (2007) have reported that Human TOB1 ... ... ... ...
 
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Entry last modified: June 2008