TGFe

[epithelial transforming growth factor] This factor of 22 kDa was isolated initially from conditioned medium of the human adrenocortical carcinoma cell line SW-13. It is found also in epithelial tissues. It is present also in normal tissues, in particular in the pituitary, plasma, and platelets.

The sequence analysis demonstrates that TGFe is a member of the protein family known as Epithelins and granulins. Biologically active truncated forms of TGFe have been described also.

TGFe supports the growth of various carcinoma cell lines (see: SW-13) in soft agar cultures (see also: Colony formation assay) and ... ... ... ...
 
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Entry last modified: March 2002