TD cells |
TD-encompassing factors |
Cas10a |
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[tumor-derived chemotactic factors] A general term for factors isolated from the conditioned medium of a number of human and murine tumor cell lines. These factors are chemotactic for mononuclear phagocytes (see also: Chemotaxis) (Bottazzi et al, 1983).
One distinct TDCF is encoded by the human JE gene (Walter et al, 1991). It belongs to the family of chemotactic cytokines known as Chemokines (subgroup of CC-Chemokines) and is one important determinant of macrophage infiltration in tumors. This TDCF is identical with MCP-1 (monocyte chemoattractant protein-1),
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