shrinkage necrosis |
shRNAs |
TGF-beta signaling protein-1 |
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gene symbol Shv. This secreted Drosophila melanogaster protein encoded by gene CG4164. The protein has been found to be necessary for the maintenance and integrity of hub cells, which form a stem cell niche shared by germline stem cells and somatic stem cells Depletion of Shriveled protein results in age-dependent deterioration of the hub structure and loss of germline stem cells, whereas upregulation of Shriveled preserves the niche during aging. Shriveled modulates DE-cadherin (fly E-cadherin) levels through extracellular activation of integrin signaling (Lee et al, 2016).
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