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Shriveled

gene symbol Shv. This secreted Drosophila melanogaster protein encoded by gene CG4164. The protein has been found to be necessary for the maintenance and integrity of hub cells, which form a stem cell niche shared by germline stem cells and somatic stem cells Depletion of Shriveled protein results in age-dependent deterioration of the hub structure and loss of germline stem cells, whereas upregulation of Shriveled preserves the niche during aging. Shriveled modulates DE-cadherin (fly E-cadherin) levels through extracellular activation of integrin signaling (Lee et al, 2016).

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