SIMU

[Six Microns Under] This Drosophila melanogaster gene (gene: CG16876) is a member of the Nimrod family of proteins and is known also as NimC4 [Nimrod C4]. The gene has been identified by Kurant et al (2008). SIMU is expressed in highly phagocytic cell types during development and required for efficient apoptotic cell clearance by glial cells in the nervous system and by macrophages elsewhere. SIMU strongly binds to apoptotic cells but requires no membrane anchoring, suggesting that it can function as a bridging molecule. Phenotypic analysis reveals that SIMU acts upstream of Draper ... ... ... ...
 
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Entry last modified: March 2014