SECRET |
SECRET domain containing protein 1 |
lycosin-I |
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[smallpox virus-encoded chemokine receptor domain] This is the name given to a unique C-terminal extension (~160 amino acids) found in the viral proteins CrmB and CrmD, both of which have anti-chemokine activity (Alejo et al, 2006). The SECRET domain binds a subset of human and mouse CC-Chemokines, CXC-Chemokines, and C-Chemokines, including CCL28, CCL25, CCL20, CXCL12, CXCL13, CXCL14, and XCL1 (Alejo et al, 2006) either independently or fused to viral tumor necrosis factor receptors (vTNFR; known as
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