crmB

[Cytokine response modifier B] This gene is encoded in the inverted terminal repeats of the DNA of the Brighton Red strain of cowpox virus. The vaccinia virus gene equivalent to crmB is called B28R/C22L. The cowpox gene is called h4r (Hu et al, 1994). Equivalent crmB genes are present also in variola virus (VARV), monkeypox virus (MPXV) (Gileva et al, 2005). The protein has been shown to contain a SECRET domain that bestows the ability to bind various chemokines (Alejo et al, 2006). The protein belongs to a larger family of secreted viral proteins with a role in immune evasion, characterized by the presence of a structural element known as PIE domain.

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Entry last modified: March 2006