Pyronecrosis

This term has been coined to describe a form of necrotic cell death observed in macrophages infected with Shigella flexneri. The process involves pattern recognition receptor NALP3 and the apoptosis regulator protein ASC [apoptosis-associated speck-like protein containing a CARD] and is associated with the release of HMG-1 [high mobility group box-1], caspase-1 and IL1-beta (Willingham et al, 2007).

Pyronecrosis is said to differ from another cell death form, pyroptosis, in that pyroptosis requires caspase-1 and pyronecrosis does not. Currently it is not known whether ... ... ... ...
 
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Entry last modified: September 2011