PDCD1
[PDCD1(+), PDCD1(-), PDCD1(high), PDCD1(low)]
[programmed cell death-1] This is called also PD-1 [programmed death-1]. Murine PDCD1 is a cell surface membrane protein belonging to the immunoglobulin superfamily. The human homolog of PD-1, PDCD1, has been isolated by Shinohara et al (1994). The amino acid sequences are 60 % identical (Finger et al, 1997). In the nomenclature of CD antigens the protein has been given the designation CD279. Another designation is Ly101. PDCD1 contains an immunoreceptor tyrosine-based switch motif, which is part of a molecular switch that allows the protein to associate with different phosphatases.
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