immunoreceptor tyrosine-based inhibitory motif |
immunoregulatory microRNAs |
CL-11 |
||
[immunoreceptor tyrosine-based switch motifs]
abbr. ITSM. The ITSM motif is a stretch of amino acids (TxYxxV/I) identified by virtue of its ability to bind to the small adaptor SH2D1A [Src homology 2 domain-containing molecule 1A] (SAP; Signaling lymphocytic activation molecule-associated protein, which is defective in X-linked lymphoproliferative disease) (Sidorenko and Clark, 2003). The ITSM, defined originally in CD150, recruits the tyrosine phosphatase SHP-2 [Src homology region 2 domain-containing phosphatase-2] to the CD150 cytoplasmic tail. In the presence of SH2D1A, the ITSM recruits SHIP [SH2-containing inositol phosphatase] to CD150
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R