NLRC2 |
NLRC4 |
APOE*4 |
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[NLR family, CARD domain containing 3] the gene encoding this protein has been identified originally as a member of the CLR family (NLR family) by Harton et al (2002) who termed it CLR16.2. The protein is known also as NOD3 [Nucleotide-binding oligomerization domain protein 3] (for nomenclature see also: Ting et al, 2008). For the zebrafish ortholog see: NLRP16
Conti et al (2005) have shown that this protein is expressed highly in T-cells. Expression is down-regulated after stimulation of primary T-cells with antibodies directed against CD3 and CD28. The presence of NLRC3 reduces
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