CD28
[CD28(+), CD28(-), CD28(int), CD28(+/-)]
This cell surface antigen is known also as T90/44 antigen or Tp44 and has been described also as Kolt-2. The CD28 gene contains 4 exons and maps to human 2q33-q34. CD28 is a 44 kDa homodimeric highly glycosylated protein which is expressed on most human T-cells. Almost all CD4(+) cells, approximately 50 % of the CD8(+) cells, and all CD4(-) CD8(+) cells express this marker. For a related protein see also: CD28H [CD28 homolog].
The biological functions of this cell surface protein are unknown. It has been shown, however, that optimal T-cell
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