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NEDD2

[Neural Precursor Cell Expressed Developmentally Downregulated 2] NEDD2 is a developmentally regulated mouse gene that encodes a protein similar to the Caenorhabditis elegans gene CED3 and mammalian ICE. Overexpression of the protein in mammalian cells induces cell death by apoptosis. The process can be blocked by expression of the apoptosis inhibitory protein BCL2 (Kumar et al, 1994)

NEDD2 is one of the caspases that play a role in cell death by apoptosis. It has been described independently as ICH-1. It has been suggested that NEDD2 be ... ... ... ... ... Subscribe to continue reading! ... ...

 

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