NDED |
NDF-alpha |
Type 3 neuroblasts |
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[neu differentiation factor] NDF has been isolated from ras-transformed fibroblasts (Peles et al, 1992; Wen et al, 1992). The protein contains an EGF-like domain and an immunoglobulin-like domain and is identical with Heregulin (human homolog) and belongs to a family of splice variants derived from neuregulins. Heregulin has been renamed neuregulin-1, and therefore NDF corresponds to a splice variant of neuregulin-1 (known as type I neuregulin-1).
The major isoforms, arising from proteolytic processing, are NDF-alpha and NDF-beta (Lu
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