NAC

[nucleotide-binding domain and CARD containing protein] Expression of this protein in vivo has been shown to be associated with terminal differentiation of short lived cells in epithelia and some other tissues.

Human NAC contains a nucleotide binding domain and a CARD domain. The CARD domain of NAC interacts selectively with the CARD domain of APAF-1, a caspase-activating protein that couples cytochrome C and the activation of cytosolic caspases within the apoptosome complex. Association of NAC with APAF-1 is inducible by cytochrome C and causes activation of caspase-9 ... ... ... ...
 
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Entry last modified: June 2008