mycetocytes |
Mycobacterium tuberculosis PPE18 |
thioredoxin peroxidase |
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DnaK is the major bacterial counterpart of the chaperone protein hsp70 [heat shock protein 70], which is one of the heat shock proteins (Hartl et al, 2011).
Prados-Rosales R et al (2011) have reported that Mycobacterium tuberculosis DnaK is found in extracellular vesicles released by Mycobacterium tuberculosis. These vesicles act on cells in a manner dependent on TLR2. Administration of these vesicles to mice before infection accelerates the pathogenesis of the disease, suggesting a function as a virulence factor.
Lopes et al (2014) have reported that Mycobacterium tuberculosis DnaK polarizes murine macrophages to assume an M2 phenotype that is associated with anti-inflammatory
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