mTEC |
M teloblasts |
Aconitase-1 |
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This is a medullary-type murine thymic epithelial cell line. The cells constitutively produce multiple species of chemotactic factors, which attract lymphocytes, neutrophils, and monocytes.
A glycosylated protein of 30 kDa has been isolated from the conditioned medium of these cells and found to be a secreted glycosylated natural form of MCP-1 (JE). The specific chemotactic activity for lymphocytes and monocytes of this 30 kDa form is lower than that of the 6-7 kDa unglycosylated form of MCP-1 (Liu et al, 1996).
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