LRRFSTMPFMFININNVINF |
LRRN6A |
StVOrth-4 |
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[leucine-rich repeat kinase 2] LRRK2 is the approved gene symbol for a gene identified independently as Dardarin and PARK8 [Parkinson disease-8; Autosomal Dominant Parkinson Disease-8]. The protein has been identified independently also as AURA17 [augmented in rheumatoid arthritis 17]. A databank synonym is RIPK7 [receptor-interacting serine/threonine kinase 7].
The gene and the cDNA have been cloned by Paisan-Ruiz et al (2004) and Zimprich et al (2004), respectively. LRRK2 possesses mixed-lineage kinase activity and also shows autophosphorylation
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