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LAIR1

[leukocyte-associated Ig-like receptor 1] In the nomenclature of CD antigens this protein has been given the designation CD305 (Warren, 2005).

LAIR1 has been identified by Meyaard et al (1997); overview: Meyaard, 2008). LAIR1 is a 32 kDa transmembrane glycoprotein with a single extracellular immunoglobulin variable domain and 2 ITIM motifs in its cytoplasmic tail that mediate inhibitory functions through the interaction with phosphatases Shp1, Shp2, and C-terminal Src kinase (Meyaard et al, 1997; Verbrugge et al, 2006, 2003). Xu et al (2000) have identified four LAIR1 isoforms/ At least one of them lacks most of the intracellular segment and also the ITIM motifs.

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