LAG-3

[lymphocyte activation gene 3] LAG-3 (approved gene symbol) is closely related to CD4 at the gene and protein levels (Triebel et al, 1990). In the nomenclature of CD antigens this protein has been given the designation CD223.

LAG3 is a structural homolog of the CD4 molecule and can bind to MHC class II with high affinity (Huard et al, 1995, 1997).

This protein has been identified as an antigen expressed on T-cells and NK-cells after cell activation. It is not expressed on resting peripheral blood lymphocytes (Triebel et al, 1990). Workman et al (2002) have reported that less than3 % ... ... ... ...
 
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Entry last modified: August 2019