lag-2 |
LAHQKPFIRKSYKCLHKRCR |
excitotoxicity |
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[LAG-3(+), LAG-3(-)]
[lymphocyte activation gene 3] LAG-3 (approved gene symbol) is closely related to CD4 at the gene and protein levels (Triebel et al, 1990). In the nomenclature of CD antigens this protein has been given the designation CD223.
This protein has been identified as an antigen expressed on T-cells and NK-cells after cell activation. It is not expressed on resting peripheral blood lymphocytes (Triebel et al, 1990). Workman et al (2002) have reported that less than3 % Alpha-Beta T-cells (memory T-cells) in the spleen and thymus of naive mice express surface CD223. Approximately 18 %
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