i-dNK-cells |
IDR-1002 |
HBEGFGF |
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[innate defense regulator peptide 1] This peptide (KSRIVPAIPVSLLamide) designed on the bases of LL-37 and other cationic host defense peptides, is an innate immune defense regulator that has been shown to be protective in murine models of infection with Gram-positive bacteria and Gram-negative pathogens, despite its complete lack of antimicrobial activity (Scott et al, 2007). Monocytes and macrophages, but not neutrophils or lymphocytes, play a key role for protection. IDR-1, like LL-37, enhances the levels of chemokines while reducing pro-inflammatory cytokine
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