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ICE-LAP3

[ICE-like apoptotic protease-3] a cystein protease involved in cell death by apoptosis (Duan et al, 1996). ICE-LAP3 is related closely to CPP32. It is identical with MCH3 (Stennicke and Salvesen, 1997). It has been suggested that ICE-LAP3 be renamed Caspase-7 (see: Caspases) (Alnemri et al, 1996).

Stennicke and Salvesen (1997) have described an optimized buffer for investigation of the characteristics of this enzyme and other Caspases.

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

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