ICAM-4 |
ICAM receptor |
Lithostathine-2 |
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In the nomenclature of CD antigens this protein has been given the designation CD50.
The gene encoding ICAM-R has been cloned by Vazeux et al (1992). The encoded protein is related to human intercellular adhesion molecules ICAM-1 and ICAM-2. Like ICAM-1 and ICAM-2, ICAM-R is a ligand for LFA-1. ICAM-R shows a high level of expression on resting leukocytes of all lineages. Its lack of expression on either resting or cytokine-activated endothelial cells indicates a pattern of expression distinct from ICAM-1 and ICAM-2.
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