ICAM1

(approved gene symbol) [intercellular adhesion molecule 1] In the nomenclature of CD antigens this protein has been given the designation CD54.

ICAM1 has been identified and named by Rothlein et al (1986) who showed that homotypic adhesion by phorbol ester-stimulated lymphocytes requires LFA-1 but does not involve like-like interactions between LFA-1 molecules on adjacent cells, which suggested the existence of a second molecule, distinct from LFA-1, that participates in LFA-1-dependent adhesion. They originally referred to the antigen as RR 1/1 antigen ... ... ... ...
 
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