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Hepatitis C virus p7 protein

[HCV p7 protein]; also p7 viroporin.

This protein is encoded in the genome of Hepatitis C virus and plays a crucial role for assembly and release of infectious virus particles (Steinmann et al, 2007). The protein can oligomerize and acts as a viroporin, disrupting membrane functions by forming cation-selective ion channels (Griffin et al, 2003, 2004; Clarke et al, 2006; Pavlovic et al, 2003; Premkumar et al, 2004).

Madan et al (2008) have reported that Hepatitis C virus p7 protein: also induces cell death by apoptosis, which is associated with activation of caspase-3.

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

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