HVEM-L

[HVEM ligand; Herpesvirus entry mediator ligand] see: HVEM. This protein has been identified by Harrop et al (1998), using an HVEM-Fc fusion protein. HVEM-L mRNA is expressed in spleen, lymph nodes, macrophages, and T-cells and encodes a 240 amino acid protein. A soluble, secreted form of the protein stimulates proliferation of T-lymphocytes during allogeneic responses, inhibits HT-29 cell growth, and weakly stimulates NF-kappa-B dependent transcription. Sequence analysis shows that the protein is identical with LIGHT.

In the nomenclature of CD antigens it has been given the designation CD258.

For additional information on CD antigens see also: ... ... ... ...
 
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