HEMbeta111-146 |
heme-binding protein |
Mast/stem cell growth factor |
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[Hemopoietic Cell Adhesion Molecule] This chicken protein has been identified and characterised by Vainio O et al (1996). Except for the amino-terminal sequence, HEMCAM is identical to gicerin and MUC18. In the nomenclature of CD antigens this antigen has received the designation CD146.
In the bone marrow the HEMCAM(+) cell population contains subsets that express c-kit, the receptor for SCF [stem cell factor]. The HEMCAM(+) c-kit(+) cell population seems to contain precursors for multiple lineages. HEMCAM promotes cell-cell adhesion of transfected cells. Cross-linking of murine HEMCAM leads to
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