HAC-1

[Drosophila melanogaster homolog of APAF-1 and CED4] This protein, encoded by gene CG6829, is the Drosophila melanogaster homolog of human APAF-1 and CED4, the corresponding gene from Caenorhabditis elegans. It has been isolated independently as Dapaf-1 and DARK (Zhou et al, 1999).

During embryonic development, HAC-1 is expressed prominently in regions where cells undergo natural death. HAC-1 has been shown to activate caspases. Its expression is induced rapidly in response to ionizing irradiation. Loss of HAC-1 results in reduced cell death by apoptosis ... ... ... ...
 
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Entry last modified: June 2003