D-Arg(6),D-Trp(7,9)-N(me)Phe(8)]-substance P(6-11) |
dark cell death |
histone H4(90-103) |
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[Drosophila melanogaster APAF-1 Related Killer] DARK is encoded by gene CG6829 and encodes a Drosophila melanogaster homolog of mammalian APAF-1 and Caenorhabditis elegans CED4 cell-death proteins (Rodriguez et al, 1999). It has been isolated independently as Dapaf-1 and HAC-1. DARK contains a carboxy-terminal WD-repeat domain that is required for interactions with the mitochondrial protein cytochrome C. This domain is found also in mammalian APAF-1 but not in nematode CED4.
DARK selectively associates with one of the
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