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GPR19

[G-protein-coupled receptor 19] The cDNA for this G-protein-coupled receptor has been cloned by O'Dowd et al (1996). GPR19 is expressed highly in the CNS of developing mouse embryos and its expression becomes limited to regions with active cell division as development progresses (Hoffmeister-Ullerich et al, 2004).

GPR19 has been identified as he receptor for Adropin (Rao and Herr, 2017; Thapa et al, 2018). Thapa et al (2018) have reported that Adropin regulates pyruvate dehydrogenase in cardiomyocytes by acting through GPR19. The authors have suggested that adropin may be a key regulator of mitochondrial fuel substrate utilization in the heart.


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