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[Glial cell line-derived neurotrophic factor] This factor was found initially in conditioned medium of the rat B49 glial cell line (referred to as B49-derived neurotrophic factor) (Lin et al, 1993, 1994).

GDNF is a disulfide-bonded homodimeric glycosylated protein of 134 amino acids (18-22 kDa on reducing SDS gels). The amino acid sequences inferred from rat and human cDNAs are 93 % identical. The proteins contain seven conserved cysteine residues in the same relative spacing found in all members of the TGF-beta superfamily of proteins. The human GDNF gene has been mapped to chromosome 5p13.1-p13.3 (Bermingham et al, 1995). Related factors are Neurturin, Persephin, and ... ... ... ... ... Subscribe to continue reading! ... ...


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