Epigen

[epithelial mitogen] abbr. EPG or EPGN. The cDNA for this factor was isolated from a gene library obtained from mouse keratinocytes due to its homology with the EGF family of growth factors (Strachan et al, 2001). Epigen encodes a protein of 152 amino acids. The gene is expressed in testis, heart, and liver. In epithelial cells, Epigen stimulates the phosphorylation of erbB1 and mitogen-activated protein kinases. Epigen stimulates the proliferation of epithelial cells.

Kochupurakkal et al (2005) have reported that Epigen cannot stimulate cells singly expressing erbB2, but it acts as a ... ... ... ...
 
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Entry last modified: March 2012