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Endosialin

The name endosialin has been proposed for the cell surface glycoprotein FB5, identified by a monoclonal antibody of the same name. The cloned sequence of endosialin (Christian et al, 2001) is identical with TEM1 [Tumor endothelial marker 1]. In the nomenclature of CD antigens this protein has been given the designation CD248.

FB5 is a tumor stromal antigen thought to be expressed selectively in vascular endothelial cells of malignant tumors. Normal blood vessels and other adult tissues lack FB5 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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