E8

a protein encoded in the genome of equine herpesvirus type 2. E8 shows sequence similarity to the death effector domains of the FADD and Caspase-8, both of which are involved in signaling cell death by apoptosis initiated through FAS antigen (see: APO-1) and TNF receptor R1. E8 is a member of a family of virus-encoded proteins designated FLIP (FLICE-inhibitory proteins).

E8 has been shown to interact with the prodomain of Caspase-8 (Bertin et al, 1997). Expression of E8 protein has been shown to protect cells apoptosis initiated through FAS antigen ... ... ... ...
 
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Entry last modified: January 2004