D blood group antigen |
dBorg-1 |
NLR family, pyrin-domain containing 8 |
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This Drosophila melanogaster is the homolog of the human pro-apoptotic BOK protein. Dbok induces cell death by apoptosis in insect and human cells, which is suppressible by anti-apoptotic human BCL2 family proteins. Dbok targets mitochondria and triggers cytochrome C release through a mechanism that is independent of the activities of caspases (Zhang et al, 2000).
Dbok has been described independently as dBorg-1, drob-1, and Debcl.
For other entries pertaining to cell death mechanisms see also the
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