CLMF p40 |
Clnk |
HIS50 |
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This protein, termed also cereolysin A, is one of the virulence factors of Bacillus cereus. It is a component of the Bacillus cereus cytolytic determinant cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes (Gilmore et al, 1989). ClnA is the Bacillus cereus homolog of Bacillus anthracis phosphatidyl choline-preferring phospholipase C and shares 99 % homology with anthralysin A.
Firth et al (2001) have reported that exogenously applied ClnA decreases cell-cell contacts, increases cell migration in epithelial cells, as well as the expression of integrins. Popova et al (2006) have reported that the isolated Bacillus anthrax hemolytic protein causes the accelerated shedding of Syndecan-1 (
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