CASH

[caspase homolog] CASH is a protein that acts as an attenuator and/or initiator in signaling for cell death by apoptosis mediated by CD95 and CD120a. The protein, of which two variants exist, contains two N-terminal death effector domains (see: death domain) and can bind through them to each other. The protein also binds to MORT-1 (FADD), and to caspases caspase-8, and caspase-10, which also participate in apoptosis (Goltsev et al, 1997).

The longer variant of CASH lacks several of the conserved caspase active site residues and probably does not possess cysteine protease ... ... ... ...
 
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Entry last modified: January 2001