CARDINAL

[CARD-inhibitor of NF-kappa-B-activating ligands] CARDINAL contains a caspase recruitment domain (CARD) and exhibits a high degree of homology to the C-terminus of DEFCAP.

The protein functions as a regulator of NF-kappa-B activation in the context of pro-inflammatory signals (Bouchier-Hayes et al, 2001). Unlike the majority of CARD proteins, CARDINAL does not promote cell death by apoptosis or activation of transcription factor NF-kappa-B. CARDINAL is a potent suppressor of NF-kappa-B activation associated with overexpression of TRAIL receptor-1, TRAIL receptor-2 (see: TRAIL), ... ... ... ...
 
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Entry last modified: July 2003