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Bacillus cereus hemolysin 2

abbr. HlyII. This protein (Coolbaugh JC and Williams RP, 1978; Baida et al, 1999) is a pore-forming toxin of the opportunistic pathogen Bacillus cereus (Miles et al, 2002). Tran et al (2011) have reported that Bacillus cereus hemolysin 2 provokes macrophage cell death by apoptosis through its pore-forming activity. The HlyII-induced apoptotic pathway depends on the expression of caspase-3 and caspase-8 and, therefore, is most likely mediated by the death receptor pathway. Deletion of hlyII strongly reduces virulence in vivo. After infection of Bombyx mori larvae, the immune cells are apoptotic, demonstrating that HlyII induces apoptosis of ... ... ... ... ... Subscribe to continue reading! ... ...

 

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