BmPP |
BMPR1B |
Type 4 receptor tyrosine kinase |
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[bone morphogenetic protein receptor type IA] abbr. BMP receptor 1a. This receptor for bone morphogenetic proteins is the same as ALK3 [Activin receptor-like kinase 3]. In the nomenclature of CD antigens this protein has been given the designation CD292.
Edson et al (2010) have reported that conditional knock-out females with a deletion of the receptor in granulosa cells are subfertile with reduced spontaneous ovulation. Double-mutant mice lacking expression of BMPR1A and ALK6 develop granulosa cell tumors that have evidence of increased TGF-beta and hedgehog
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