Hedgehog

symbol: Hh. This Drosophila melanogaster protein is encoded by gene CG4637. Hedgehog is a segment polarity gene essential for a variety of patterning events during development such as the establishment of the anterior-posterior axis of embryonic segments and patterning of the larval imaginal disks. The name derives from the phenotype of mutants obtained in a search for mutations affecting embryonic cuticular patterns, which causes an embryo to be covered with pointy denticles (bristles), thus resembling a hedgehog (Nüsslein-Volhard and Wieschaus, 1980).

Mandal et al (2007) have implicated hedgehog in the maintenance of hematopoietic precursor cells within the developing third-instar lymph gland. In the absence of a Hedgehog signal, the precursor population of the medullary zone is lost because cells ... ... ... ...
 
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Entry last modified: September 2012