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BCRP

[breast cancer resistance protein] Also: BCRP1 [breast cancer resistance protein-1]

This ATP binding cassette gene has been characterized by Doyle et al (1998) who observed that enforced expression of the BCRP gene in MCF-7 breast cancer cells confers resistance to various chemotherapeutic drugs (mitoxantrone, doxorubicin, daunorubicin. Expression of BCRP reduces daunorubicin accumulation and retention, and causes an ATP-dependent enhancement of the efflux or rhodamine-123. The authors have concluded that BCRP is a xenobiotic transporter with a major role in the multidrug resistance phenotype of a specific human breast cancer.

In the nomenclature of CD antigens this protein has been given the designation ... ... ... ... ... Subscribe to continue reading! ... ...

 

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