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BAG2

(approved gene symbol) [BCL2-associated athanogene-2] In some databanks the protein is being referred to also as BAG family molecular chaperone regulator 2.

This protein is related to BAG1 and shares a so-called BAG domain located near the C-terminus with BAG1, BAG3, BAG4, and BAG5 (Takayama et al, 1999). The protein interacts specifically with the ATPase domain of the chaperone hsp70 and inhibits its chaperone activity. This interaction or interactions with BCL2 may also be responsible for its anti-apoptotic activities (Doong et al, 2002).

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