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B-cell growth inhibitory factor

abbr. BIF (a term with multiple meanings). This biochemically uncharacterized factor of approximately 80 kDa was found in conditioned medium of Con A-activated human peripheral blood mononuclear cells. It is an inhibitor of antigen-stimulated B-cells proliferation and clonal expansion induced by B-cell growth factors (see: BCGF) (Kawano et al, 1985, 1989).

BIF does not inhibit the proliferation of murine 3T3 fibroblasts, murine myeloma cell line NS-1, human lymphoid cell lines (MOLT-4, HSB-2, and DAUDI), or a human ... ... ... ... ... Subscribe to continue reading! ... ...

 

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