ATG12
[autophagy-related-12] (approved gene symbol) Other designations for this protein are APG12 [autophagy gene 12] and APG12L [APG12-like]. The cDNA has been cloned independently as FBR93.
ATG12 is a protein important for early steps of autophagy (autophagosome formation) in an ubiquitin-like protein conjugation step. ATG12 covalently attaches to the target protein ATG5 (Mizushima et al, 1998, 1998). ATG12 is activated in an ATP-dependent process by ATG7, a ubiquitin-like E1 activating enzyme (Tanida et al, 1999). Subsequently, ATG12 is conjugated to ATG5 by ATG10
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