ADAM22

[a disintegrin and metalloprotease domain 22; ADAM metallopeptidase domain 22] This protein is a member of the ADAM protein family (Sagane et al, 1999). The gene symbol and alternative name is MDC-2 [metalloproteinase-like disintegrin-like cysteine-rich protein-2], for which many different variants have been described.

Sequence analysis suggests that ADAM11 is not a metalloprotease, since it lacks a catalytic motif (Sagane et al, 1998; Sagane et al, 1999). The presence of a functional disintegrin-like and cysteine-rich sequence in the ectodomain of ADAM22 suggests that the protein functions as an adhesion molecule or a receptor. ADAM11 has been shown to be a binding receptor for LGI1 ... ... ... ...
 
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Entry last modified: June 2009