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The vav oncogene (designated vav-1) was found to be generated by a genetic rearrangement during gene transfer assays. The oncogene is activated by genetic rearrangements leading to the truncation of aminoterminal sequences. vav maps to human chromosome 19p12-19p13.2 and is closely linked to the insulin receptor. Chromosome region 19p13 is involved in different karyotypic abnormalities in a variety of malignancies including melanomas and leukemias. For related genes see: vav-2, vav-3.

The vav cDNA encodes an open reading frame of 2391 nucleotides capable of directing the synthesis of a protein of 797 amino acids (95 kDa). The vav ... ... ... ... ... Subscribe to continue reading! ... ...

 

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