stemness

a noun pertaining to the ability of cells to behave like true stem cells, i.e. to undergo asymmetric cell division that yields two types of daughter cells, namely those that retain their totipotent nature (self-renewal), and those (progenitor cells) that have a restricted differentiation potential (see also: MRA [marrow repopulating ability]). This concept of stemness also appears to apply to many cancers (see: neoplastic stem cells).

Maintenance of stemness depends on the ability of cells to express certain genes such as those encoding transcription factors (see also: Reprogramming) and/or suppress the expression of others. Some proteins such as the ... ... ... ...
 
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Entry last modified: December 2019