sickle

symbol: skl. Sickle (108 amino acids), encoded by gene CG13701, has been identified as a Drosophila melanogaster cell death protein. The protein contains an RHG motif. The protein is being referred to also as Veto (Holcik, 2002), and is found as mephisto in databanks.

Sickle binds to inhibitors of apoptosis proteins (IAP) and neutralizes the anti-apoptotic activity of the Drosophila melanogaster proteins DIAP1 and DIAP2 or the baculovirus p35 protein through interactions with the BIR domain ... ... ... ...
 
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Entry last modified: June 2003